Health‐related quality of life in Huntington's disease: Which factors matter most?
Identifieur interne : 002279 ( Main/Exploration ); précédent : 002278; suivant : 002280Health‐related quality of life in Huntington's disease: Which factors matter most?
Auteurs : Aileen K. Ho [Royaume-Uni] ; Abigail S. Gilbert [Royaume-Uni] ; Sarah L. Mason [Royaume-Uni] ; Anna O. Goodman [Royaume-Uni] ; Roger A. Barker [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-03-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Cognition, Cognition Disorders (etiology), Depression, Depression (etiology), Disability Evaluation, Female, Functional capacity, Health Status, Humans, Huntington Disease (complications), Huntington Disease (psychology), Huntington disease, Huntington's disease, Male, Middle Aged, Mood, Motor Activity (physiology), Nervous system diseases, Neuropsychological Tests, Quality of Life (psychology), Quality of life, Regression Analysis, SF‐36, Severity of Illness Index, cognition, depressive mood, functional capacity, health‐related quality of life, motor.
- MESH :
- complications : Huntington Disease.
- etiology : Cognition Disorders, Depression.
- physiology : Motor Activity.
- psychology : Huntington Disease, Quality of Life.
- Adult, Disability Evaluation, Female, Health Status, Humans, Male, Middle Aged, Neuropsychological Tests, Regression Analysis, Severity of Illness Index.
Abstract
The aim of this article was to determine which aspects of Huntington's disease (HD) are most important with regard to the health‐related quality of life (HrQOL) of patients with this neurodegenerative disease. Seventy patients with HD participated in the study. Assessment comprised the Unified Huntington's Disease Rating Scale (UHDRS) motor, cognitive and functional capacity sections, and the Beck Depression inventory. Mental and physical HrQOL were assessed using summary scores of the SF‐36. Multiple regression analyses showed that functional capacity and depressive mood were significantly associated with HrQOL, in that greater impairments in HrQOL were associated with higher levels of depressive mood and lower functional capacity. Motor symptoms and cognitive function were not found to be as closely linked with HrQOL. Therefore, it can be concluded that, depressive mood and greater functional incapacity are key factors in HrQOL for people with HD, and further longitudinal investigation will be useful to determine their utility as specific targets in intervention studies aimed at improving patient HrQOL, or whether other mediating variables. As these two factors had a similar association with the mental and physical summary scores of the SF‐36, this generic HrQOL measure did not adequately capture and distinguish the true mental and physical health‐related HrQOL in HD. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22412
Affiliations:
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Le document en format XML
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Mason</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cambridge Centre for Brain Repair, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Goodman, Anna O" sort="Goodman, Anna O" uniqKey="Goodman A" first="Anna O." last="Goodman">Anna O. 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-03-15">2009-03-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="574">574</biblScope><biblScope unit="page" to="578">578</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">9C4459C424E30FD2C62D650640E5E04125847CDE</idno><idno type="DOI">10.1002/mds.22412</idno><idno type="ArticleID">MDS22412</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Cognition</term><term>Cognition Disorders (etiology)</term><term>Depression</term><term>Depression (etiology)</term><term>Disability Evaluation</term><term>Female</term><term>Functional capacity</term><term>Health Status</term><term>Humans</term><term>Huntington Disease (complications)</term><term>Huntington Disease (psychology)</term><term>Huntington disease</term><term>Huntington's disease</term><term>Male</term><term>Middle Aged</term><term>Mood</term><term>Motor Activity (physiology)</term><term>Nervous system diseases</term><term>Neuropsychological Tests</term><term>Quality of Life (psychology)</term><term>Quality of life</term><term>Regression Analysis</term><term>SF‐36</term><term>Severity of Illness Index</term><term>cognition</term><term>depressive mood</term><term>functional capacity</term><term>health‐related quality of life</term><term>motor</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term><term>Depression</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Motor Activity</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Huntington Disease</term><term>Quality of Life</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Disability Evaluation</term><term>Female</term><term>Health Status</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Regression Analysis</term><term>Severity of Illness Index</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Capacité fonctionnelle</term><term>Chorée de Huntington</term><term>Cognition</term><term>Etat dépressif</term><term>Humeur</term><term>Pathologie du système nerveux</term><term>Qualité de vie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this article was to determine which aspects of Huntington's disease (HD) are most important with regard to the health‐related quality of life (HrQOL) of patients with this neurodegenerative disease. Seventy patients with HD participated in the study. Assessment comprised the Unified Huntington's Disease Rating Scale (UHDRS) motor, cognitive and functional capacity sections, and the Beck Depression inventory. Mental and physical HrQOL were assessed using summary scores of the SF‐36. Multiple regression analyses showed that functional capacity and depressive mood were significantly associated with HrQOL, in that greater impairments in HrQOL were associated with higher levels of depressive mood and lower functional capacity. Motor symptoms and cognitive function were not found to be as closely linked with HrQOL. Therefore, it can be concluded that, depressive mood and greater functional incapacity are key factors in HrQOL for people with HD, and further longitudinal investigation will be useful to determine their utility as specific targets in intervention studies aimed at improving patient HrQOL, or whether other mediating variables. As these two factors had a similar association with the mental and physical summary scores of the SF‐36, this generic HrQOL measure did not adequately capture and distinguish the true mental and physical health‐related HrQOL in HD. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li></region><settlement><li>Cambridge</li></settlement><orgName><li>Université de Cambridge</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Ho, Aileen K" sort="Ho, Aileen K" uniqKey="Ho A" first="Aileen K." last="Ho">Aileen K. Ho</name></noRegion><name sortKey="Barker, Roger A" sort="Barker, Roger A" uniqKey="Barker R" first="Roger A." last="Barker">Roger A. Barker</name><name sortKey="Gilbert, Abigail S" sort="Gilbert, Abigail S" uniqKey="Gilbert A" first="Abigail S." last="Gilbert">Abigail S. Gilbert</name><name sortKey="Goodman, Anna O" sort="Goodman, Anna O" uniqKey="Goodman A" first="Anna O." last="Goodman">Anna O. Goodman</name><name sortKey="Mason, Sarah L" sort="Mason, Sarah L" uniqKey="Mason S" first="Sarah L." last="Mason">Sarah L. Mason</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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